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The Northwest business that has investors buzzing right now is the Seattle biotech company Juno Therapeutics. It’s going public Friday morning and hopes the IPO will raise more than $200 million. It will trade on the Nasdaq under JUNO.

Juno Therapeutics specializes in immunotherapies to treat leukemia and lymphoma. This involves taking a person’s T-cells, the ones that fight infections in our bodies, and reengineering them to become stronger.

clerk.seattle.gov

Settling ground is affecting the Alaskan Way viaduct, Pioneer Square buildings and underground water pipes, Seattle utilities officials said Monday. Engineers think the sinking is connected to the Highway 99 tunnel project, but it probably has little to do with actual digging.

net_efekt / Flickr

The occasional home visit from a health worker can be strong medicine for people who suffer from asthma. A new study based in King County shows it can have as much benefit, and cost even less, than prescription drugs.

Elaine Thompson / AP Photo

State health officials are putting a positive spin on the bumpy rollout of the state’s health insurance exchange.

Over the weekend, the Washington Healthplanfinder website shut down just a few hours after it opened for business. It’s now back online after a glitch involving tax credit calculations was fixed.

Cynthia Goldsmith / Centers for Disease Control and Prevention

Scientists from the University of Washington have managed to get lab mice with Ebola to mimic the symptoms of infected humans. And the findings show genes play a big role in how sick people get.

Scientists want to understand why Ebola makes some people terribly sick and gives others much milder symptoms. Now UW researchers have gotten mice to show a similar range of responses — something that has long eluded scientists. The new development could help them understand exactly how the virus takes its toll, and potentially speed up vaccine and drug development.

Gerry Lauzon / Flickr

A new study finds girls treated with radiation for a rare childhood cancer are much more likely to develop breast cancer as young women. The Seattle scientist who led the study said it shows some kinds of radiation therapy can be risky for children even at relatively low doses.  

The study looked at kids with Wilms tumor, a rare kidney cancer diagnosed in just 500 or so North Americans a year. The study has been going on for 45 years, and statistician Norman Breslow of the University of Washington and the Fred Hutchinson Cancer Research Center has been with it all along.

chichacha / Flickr

A love for coffee may run deep in the Northwest, but now a Seattle scientist says the craving for coffee seems to be written into some people’s DNA.

Researchers from Harvard University, the Fred Hutchinson Cancer Research Center and elsewhere sifted through the genes of more than 100,000 people, looking for common variants that correlate with heavy coffee consumption. They zeroed in on eight genetic variations associated with that deep compulsion to hoist a mug of joe.

Washington State University

A team of scientists has come up with a way to search for water on Mars, and the person behind much of the research is a Washington State University undergraduate.

At age 19, Kellie Wall was planning to major in communications. She needed a science credit and wound up in a geology course with a professor who was a big believer in undergrads getting research experience. There, Wall learned about a project involving volcanoes and other planets.

“I was really excited about it because there was this buzzword Mars attached to it,” she said.

Gabriel Spitzer / KPLU

Surgeons at Swedish Medical Center in Seattle treated a patient for metastatic brain cancer last week with sound in what is believed to be the first procedure of its kind in the world.

Besides drugs, there used to be basically one tool for attacking attack brain cancer: a knife. Scientists have been developing less and less invasive ways to get at brain tumors, and now an early-stage trial at Swedish Neuroscience Institute has shown surgeons can treat a metastatic tumor with high-frequency sound beamed painlessly through the skull.

University of Washington

A researcher in genetics at the University of Washington has won a prominent award, sometimes referred to as the American version of the Nobel Prize, in part for a key contribution to understanding breast cancer.

Mary-Claire King knew that breast cancer runs in some families, but it wasn’t clear why. In the 1970s and '80s, genetic research was much more cumbersome and expensive than it is today, and the very idea that a gene could trigger a complex disease like cancer was controversial.

Kaytee Rlek / Flickr

Seattle scientists have zeroed in on a part of the brain that seems to have an interesting job: motivating the brain’s owner to exercise. The findings could have implications for understanding depression.

The dorsal medial habenula is a little structure tucked inside the brain, above the brainstem. Psychiatrist Eric Turner of Seattle Children’s Research Institute knew it had something to do with regulating mood, but not a lot more.

“People asked me, 'Well, what does it do?' And I actually didn’t know. And when I looked it up I found that very little is known about this area of the brain,” he said.

Texas A&M University Press

A skeleton some 9,000 years old is giving up a few of his secrets. A new book about the so-called Kennewick Man, whose remains were found 18 years ago, is due to hit bookstands in mid-September.

Kennewick Man was found resting in the shallow water of the Columbia River. His early story was that of some strife; a rock-point was found buried in his hip bone.

Zack Gainsforth

An unmanned NASA research mission led by a Seattle scientist has caught what are believed to be seven tiny pieces of distant stars and brought them back to Earth.

The Stardust Mission sent a spacecraft on three trips around the sun, dipping into an extremely faint jet of interstellar particles flowing into the solar system. It grabbed seven motes of interstellar dust, giving us a glimpse of what stars other than the Sun are like.

Alison Marcotte / KPLU

Here’s a thought experiment: You’re a scientist researching a treatment for depression, and you’ve become profoundly depressed. Your work is slow and painstaking, and involves methodical experiments with monkeys. It’s likely years before anything you might discover would become available for people.

Gerry Broome / AP Photo

For someone with cancer who lives far from a big city, it can be hard to access cutting-edge care, but a network of Northwest hospitals is getting millions to bring clinical cancer trials to far-flung communities.

Clinical trials study experimental drugs and therapies, and they're the main tool for bringing new treatments to market. But they can also have more immediate benefits for the people enrolled in a study.

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